In-Depth Characterization of the Effects of Cigarette Smoke Exposure on the Acute Trauma Response and Hemorrhage in Mice.
MouseHaemorrhage/shockUnspecifiedMaleIntravenous for fluids and noradrenaline; mechanical ventilationNoradrenaline titrated to maintain mean arterial pressure a…Started after 1 h of haemorrhagic shock and continued for 4 h
Model: Blunt chest trauma plus haemorrhagic shock for 1 h after 3 weeks of cigarette smoke exposure, followed by 4 h of intensive care therapy
Cigarette smoke exposure with blunt chest trauma and haemorrhagic shock produced haemodynamic instability, acute kidney injury and high mortality despite resuscitation.
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