Lithium Inhibits GSK3beta Activity via Two Different Signaling Pathways in Neurons After Spinal Cord Injury.
MouseSpinal cord injuryUnspecifiedC57BL/6MaleAcute and chronic phases after injury examined
Model: Spinal cord injury with parallel studies in cultured spinal cord neurons
Lithium inhibited GSK3 beta through AKT phosphorylation acutely and through Na,K-ATPase alpha1 and SGK1 chronically, raising nuclear beta-catenin and supporting neuronal survival.
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