BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury.
MouseRadiationC57BL/6J, plus Lgr5-eGFP-IRES-CreERT2 and Rosa26 reporter linesMalen = Minimum n = 25 per group for survival; n = 10 per group for…Subcutaneous90 mg/kg body weight, 12 mg/mL in 30 per cent Captisol give…First dose 24 h after irradiation; a first dose delayed to 72 h was ineffective
Model: Radiation-induced gastrointestinal syndrome after abdominal irradiation of 14 to 16 Gy, or 14.5 Gy partial body irradiation with 40 per cent bone marrow shielding
BCN057 started 24 h after lethal abdominal irradiation rescued Lgr5 positive intestinal stem cells, restored epithelial integrity and improved survival, without radioprotecting colon tumour tissue.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.