Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGFbeta1.
RatOtherSprague-DawleyMalen = 135 rats, 45 per group, with 5 per group per time point for…Local implantation into a trough at the humeral footprint tendon-bone interface2 mg hydroxyapatite powder, loaded with TGF-beta1 at 10 mic…At the time of repair surgery
Model: Acute rotator cuff tear model with the supraspinatus tendon sharply detached from the greater tuberosity and repaired transosseously
Hydroxyapatite with TGF-beta1 increased bone mineral density, fibrocartilage area, collagen organisation and load to failure compared with repair alone, with the greatest advantage at 2 and 4 weeks.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.