The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice.
MouseRadiationC57BL/6NTac (C57BL/6 for the 10 Gy bone marrow transplantation experiments)Femalen = N = 3 mice per group for tissue, RNA and histology endpoint…Intravenous20 mg/kg, approximately 400 micrograms per mouse24 hours after total body irradiation
Model: Total body irradiation at 9.25 Gy or 9.5 Gy delivered in a caesium irradiator at 76 cGy/min; 10 Gy or 15 Gy total body or abdominal irradiation used in additional experiments
A single intravenous dose of JP4-039 given 24 hours after 9.25 Gy or 9.5 Gy total body irradiation raised 35 day survival from 25 per cent and 10 per cent respectively to 75 per cent. Treatment halved goblet cell loss, restored enteroendocrine cell numbers by day 12, recovered tight junction transc…
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