Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model.
RatWoundSprague-DawleyFemale (virgin)n = 60 rats randomised to four groups: saline plus cells n = 15…Local injection into both ends of the external anal sphincter (30 and 330 degrees on a superimposed clock face) with a 25-gauge needleFour injections per animal with a total injection volume of…Immediately after sphincter transection and repair, before closure of the perin…
Model: Surgical transection of the external and internal anal sphincter and anal mucosa to mimic an acute fourth degree sphincter tear, followed by repair with 6-0 poliglecaprone continuous sutures
Both human adipose stem cell groups showed significantly higher median resting and peak contraction pressures than the cell-free controls at 2 weeks (resting 9.3 and 9.6 versus 4.9 and 5.2 mmHg, p < 0.001) and at 4 weeks (10.1 and 9.2 versus 5.4 and 6.1 mmHg, p = 0.005), with no difference between…
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