Evaluation of the Effect of Topical Application of Nigella sativa on Acute Radiation-Induced Nasal Mucositis.
RatRadiationn = 18 rats in total, 6 per group across 3 groupsTopical intranasalOne drop of 0.05 mL per nostrilFrom the first day after radiotherapy
Model: Single 40 Gy irradiation of the nasal and paranasal area producing acute radiation-induced nasal mucositis; sham irradiation in the control group
No mucositis was seen in the sham-irradiated group. Of the graded histopathological parameters, only superficial erosion differed significantly between irradiated saline and irradiated Nigella sativa animals (p < 0.05), although overall microscopic appearances were reported as better in the treated…
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