Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord.
RatSpinal cord injuryContusionSprague Dawleyn = Six animals per injection group (PBS and iOA), from startin…Intraspinal injection into the lesion using a 34 gauge needle6 microlitres injected at 1 microlitre per minute; hydrogel…One week after injury
Model: Unilateral cervical contusion spinal cord injury; laminectomy at C3/C4 and Infinite Horizon impactor, 2.5 mm tip, 200 kDyn set force
iOA shifted the M1:M2 macrophage ratio from 1.88 to 0.635 and increased distal axonal coverage at eight weeks but gave no locomotor or respiratory functional benefit and no change in glial scarring or spared tissue.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.