PRECLINICAL PUBLICATION · 2018

Noninvasive, targeted gene therapy for acute spinal cord injury using LIFU-mediated BDNF-loaded cationic nanobubble destruction.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

BDNF-loaded cationic nanobubbles conjugated with MAP-2 antibody, destroyed by low-intensity focused ultrasound

PMID 29360450 ↗2018Reported benefit

Noninvasive, targeted gene therapy for acute spinal cord injury using LIFU-mediated BDNF-loaded cationic nanobubble destruction.

RatSpinal cord injuryUnspecifiedSprague-DawleyMaleUltrasound-targeted delivery to the injured spinal cordApplied after acute spinal cord injury

Model: Acute spinal cord injury in rats

Low-intensity focused ultrasound mediated delivery increased BDNF expression, attenuated histological injury, reduced neuronal loss and apoptosis and improved BBB scores.

Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.