Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models.
MouseChemical/toxinC57BL/6Malen = Carbon tetrachloride experiment 60 mice in six groups of 10…Oral gavage (methylprednisolone intraperitoneal)3, 15 and 75 mg/kg (3 mg/kg in the carbon tetrachloride exp…Pretreatment, with injury induced on the third day alongside the final dose
Model: Two acute hepatitis models: carbon tetrachloride 100 microlitres/kg intraperitoneally in olive oil with sacrifice at 24 hours, and concanavalin A 10 mg/kg intravenously with sacrifice at 8 hours
The extract gave marked dose-dependent protection in the carbon tetrachloride model, with AST down 91% and ALT down 88% at 75 mg/kg, but had no significant effect in the concanavalin A model.
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.