Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1.
MouseEndotoxin/LPSC57BL/6MaleAcute downregulation in the setting of sepsis-induced lung injury
Model: Sepsis-induced acute respiratory distress syndrome; lipopolysaccharide stimulation of alveolar macrophages and a sepsis-induced acute lung injury model
Downregulating miR-199a reduced alveolar macrophage inflammatory cytokines, improved lung histopathology and reduced apoptosis via upregulation of SIRT1, with the benefit lost when SIRT1 was inhibited.
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.