Antiulcer activity of methanol-chloroform extract of Channa striatus fillet.
RatChemical/toxinSprague-DawleyMaleOral50, 250 and 500 mg/kgPretreatment before ulcer induction
Model: Ethanol-induced and indomethacin-induced gastric ulcer, plus a pyloric ligation model for antisecretory activity
The extract significantly reduced gastric ulceration in both models through a cytoprotective, sulfhydryl-dependent mechanism, without an antisecretory effect; protection was reversed by N-ethylmaleimide but not L-NAME.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.