Acute downregulation of miR-155 leads to a reduced collagen synthesis through attenuating macrophages inflammatory factor secretion by targeting SHIP1.

Acute downregulation of miR-155 leads to a reduced collagen synthesis through attenuating macrophages inflammatory factor secretion by targeting SHIP1.

Model: Severe burn with skin fibrosis, plus in vitro macrophage and fibroblast co-culture

Downregulation of miR-155 reduced macrophage TGF-beta1 and IL-1beta secretion, fibroblast proliferation and collagen synthesis, and reduced fibrosis in severely burned rats.

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.