Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modify Microglial Response and Improve Clinical Outcomes in Experimental Spinal Cord Injury.
RatSpinal cord injuryContusionSprague-DawleyMalen = Behaviour: sham 6, injury plus vehicle 6, naive vesicles 8,…Intravenous, tail veinSingle 1 ml injection of extracellular vesicle preparation…3 h after injury
Model: T10 laminectomy with moderate contusion spinal cord injury using an Infinite Horizon impactor at 150 kdyne with 1 s dwell, dura intact
Intravenous mesenchymal stromal cell-derived extracellular vesicles improved BBB locomotor scores at days 5, 7 and 14 and raised mechanical withdrawal thresholds relative to vehicle, with reduced microglial activation near the injury epicentre; cytokine-stimulated vesicles gave a higher mechanical…
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