Necrostatin-1 Protects Against Paraquat-Induced Cardiac Contractile Dysfunction via RIP1-RIP3-MLKL-Dependent Necroptosis Pathway.
MouseChemical/toxinC57BL/6Pre-treatment before paraquat challenge
Model: Paraquat-induced acute cardiac contractile dysfunction
Paraquat challenge impaired contractile function, deranged intracellular calcium handling and produced echocardiographic abnormalities together with raised RIP1, RIP3 and MLKL expression and reactive oxygen species overproduction. Necrostatin-1 pre-treatment prevented the cardiac contractile dysfun…
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