Protective effect of hydroxysafflor yellow A on bleomycin-induced pulmonary inflammation and fibrosis in rats.
RatChemical/toxinWistarn = n=8 or 12 per group across 6 groupsIntraperitoneal35.6, 53.3 and 80.0 mg/kg/dayCommenced after bleomycin administration
Model: Bleomycin-induced acute lung inflammation and chronic pulmonary fibrosis
Hydroxysafflor yellow A ameliorated lung inflammation at day 7 and fibrosis at day 21, raised PaO2 and lowered PaCO2, and reduced TNF-alpha, IL-1beta and IL-6 mRNA and NF-kappaB p65-positive cell numbers at 53.3 and 80.0 mg/kg. At the same doses it attenuated the increases in TGF-beta1, alpha-SMA a…
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