Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury.
RatChemical/toxinSprague-DawleyMalen = Pharmacokinetic experiment 12 rats (6 per group); pharmacod…Oral5 g/kg2 h after surgery (model induction)
Model: Acute pancreatitis with multiple organ injury induced by retrograde perfusion of 3.5% sodium taurocholate into the biliopancreatic duct at 1 mL/kg body weight, infused at 6 mL/h
Acute pancreatitis altered the pharmacokinetics of individual components, accelerating clearance of emodin and aloe-emodin, increasing rhein exposure and slowing chrysophanol. Treated rats had significantly higher IL-10 and lower TNF-alpha than the untreated model group, and significantly lower his…
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