Injectable hydroxyphenyl derivative of hyaluronic acid hydrogel modified with RGD as scaffold for spinal cord injury repair.
RatSpinal cord injuryHemisection / partialWistarMaleIntralesional injection or implantation into the spinal cord lesion cavityAcute (into the hemisection cavity) and subacute injection models
Model: Acute spinal cord hemisection and subacute spinal cord injury
Injection and implantation of the hydrogel into the acute hemisection cavity gave the same axonal and blood vessel density at 2 and 8 weeks. Subacute injection of the hydrogel with or without fibrinogen similarly promoted axonal ingrowth into the lesion, and this was further enhanced when the fibri…
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