Attenuated accumulation of regulatory T cells and reduced production of interleukin 10 lead to the exacerbation of tissue injury in a mouse model of acute respiratory distress syndrome.

Attenuated accumulation of regulatory T cells and reduced production of interleukin 10 lead to the exacerbation of tissue injury in a mouse model of acute respiratory distress syndrome.

Model: Intratracheal alpha-galactosylceramide followed by lipopolysaccharide-induced acute respiratory distress syndrome

Recombinant IL-10 prolonged survival and attenuated lung injury, with reduced production of inflammatory cytokines and chemokines in alpha-galactosylceramide/LPS treated mice.

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