Human Umbilical Cord Blood CD45Pan-Hematopoietic Cells Induced a Neurotherapeutic Effect in Mice with Traumatic Brain Injury: Immunophenotyping, Comparison of Maternal and Neonatal Parameters, and Immunomodulation.
MouseTBIClosed-head / concussionC57BL/6JMaleIntravenous xenotransplantation
Model: Moderate closed-head traumatic brain injury
CD45+ cell transplantation improved motor and memory recovery independent of delivery type and produced an acute immunomodulatory effect in the injured cortex. CD45 expression in mononuclear cells was highly heterogeneous across both vaginal and caesarean units.
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