Prokinetic effects of neurokinin-2 receptor agonists on the bladder and rectum of rats with acute spinal cord transection.
RatSpinal cord injuryComplete transectionSprague-DawleyFemaleIntravenous, subcutaneous, intramuscular, intranasal and sublingualLMN-NKA 1 to 10 micrograms/kg IV, 10 to 300 micrograms/kg S…Acutely after spinalisation, in anaesthetised rats
Model: Acute spinal cord transection under anaesthesia
All routes produced rapid-onset, short-duration, dose-related increases in bladder pressure and voiding, with onset and duration ranked IV < IN < SC = IM < SL and voiding efficiency around 70 per cent. Vehicle never produced contractions or voiding. Transient hypotension followed intravenous LMN-NK…
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