Citrullus colocynthis Linn. Fruit extract ameliorates cisplatin-induced hepato-renal toxicity in rats.
RatChemical/toxinWistar (albino)Malen = 30 rats in 5 groups of 6Oral (p.o.)100, 200 or 400 mg/kgPretreatment for 10 days with cisplatin given on day 7, one hour after extract…
Model: Cisplatin (7.5 mg/kg intraperitoneal) induced hepato-renal toxicity
Citrullus colocynthis at 100 to 400 mg/kg attenuated cisplatin-induced rises in ALT, ALP, creatinine and blood urea nitrogen, normalised haematological changes, reduced malondialdehyde and nitrite, restored glutathione, catalase and superoxide dismutase, and preserved liver and kidney histoarchitec…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.