Parallel Evaluation of Two Potassium Channel Blockers in Restoring Conduction in Mechanical Spinal Cord Injury in Rat.
RatSpinal cord injuryUnspecifiedSprague-DawleyMaleIntraperitoneal4-AP-3-MeOH 1 and 5 mg/kg; 4-AP 1 mg/kgApplied in rats 2 weeks after spinal cord injury
Model: Mechanical spinal cord injury, ex vivo and in vivo
4-AP-3-MeOH produced significantly greater augmentation of axonal conduction than 4-AP in both acute and chronic injury without reducing responsiveness to multiple stimuli, was tolerated at a dose at least 5 times higher than 4-AP, improved motor function at 5 mg/kg, and both agents alleviated neur…
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