Gamma-Secretase Inhibitors Attenuate Neurotrauma and Neurogenic Acute Lung Injury in Rats by Rescuing the Accumulation of Hypertrophic Microglia.
RatTBIUnspecifiedSprague-DawleyMaleSubcutaneous injectionLY411575 5 mg/kg; CHF5074 30 mg/kgImmediately after traumatic brain injury
Model: Traumatic brain injury with secondary neurogenic acute lung injury
Both gamma-secretase inhibitors significantly attenuated accumulation of hypertrophic microglia in the injured cortex, reduced neurological injury and attenuated neurogenic acute lung injury assessed 4 days after traumatic brain injury.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.