Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy.
RatChemical/toxinSprague-DawleyFemale (pregnant dams, fetal liver assessed)Given before induction of acute pancreatitis in pregnancy
Model: Sodium taurocholate-induced acute pancreatitis in pregnancy with secondary fetal liver injury
ISO-1 ameliorated pathological injury in maternal pancreas and fetal liver, reduced maternal serum TNF-alpha and IL-1 beta and lowered fetal liver MIF, myeloperoxidase, NF-kappaB, HMGB1, TNF-alpha and IL-1 beta.
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