Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity.
RatChemical/toxinWistarMalen = 84 male rats in total, 21 per group across four groupsIntraperitoneal1 microgram/kg
Model: Isoproterenol-induced myocardial injury, isoproterenol 85 mg/kg/day intraperitoneally
Periostin reduced the levels of the analysed markers, most notably cardiac troponins and creatine kinases, on days 7 and 28 after induced heart damage, which the authors interpret as a potential to increase the rate of myocardial recovery.
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