Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage.
RatHaemorrhage/shockUnspecifiedSprague-DawleyMalen = 80 rats for the collagenase model (9 per group for MRI, 14…Intraventricular injection into the lateral ventricle ipsilateral to the lesionSuspended in 10% PEG-45 hydrogenated castor oil at 4 mmol/L…10 min after induction of intracerebral haemorrhage
Model: Intrastriatal collagenase-induced intracerebral haemorrhage, confirmed in a second model of autologous blood injection (30 microlitres of tail vein blood infused into the striatum over 10 min)
Pyr3 reduced haematoma size at 3, 12, 15 and 21 h, lowered T2-weighted and diffusion-weighted signal ratios, reduced blood-brain barrier leakage on Ktrans at 3 and 15 h, decreased perihaematomal GFAP-positive astrocyte accumulation and improved grip strength, rotarod performance and neurological de…
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