Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury.
MouseCrushPeripheral-nerve crushC57BL/6Intravitreal and intraperitoneal1 to 10 micromolar intravitreally; 2 to 10 mg/kg intraperit…Intravitreal injection immediately after optic nerve crush
Model: Optic nerve crush
A single intravitreal injection prevented histone deacetylation, heterochromatin formation, apoptosis and DNA damage at 5 and 7 days after crush. Retinal drug concentration after intraperitoneal injection peaked within 1 h then declined rapidly. A single intraperitoneal dose of 2 to 10 mg/kg preven…
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