Ulcer Prevention Effect Of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol-3yl)Methylidene]Benzohydrazide In HCl/Ethanol-Induced Gastric Mucosal Damage In Rats.
RatChemical/toxinSprague-DawleyMale for the ulcer prevention study and female for the acute toxicity studyn = 6 rats per group in six groups for the ulcer study, and 6 r…Oral gavage50, 100 and 200 mg/kg for the ulcer study; 300 and 2000 mg/…60 min before the HCl/ethanol challenge
Model: HCl/ethanol-induced gastric mucosal damage, 5 mL/kg of 150 mM HCl in absolute ethanol (40:60 v/v) by oral gavage after a 24 h fast
TIBH gave dose-dependent reduction in ulcer area comparable with omeprazole, lowered gastric acidity, increased gastric mucus and periodic acid-Schiff staining at medium and high doses, reduced submucosal oedema and leucocyte infiltration, upregulated HSP70, downregulated Bax, decreased malondialde…
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