Multilayer polyion complex nanoformulations of superoxide dismutase 1 for acute spinal cord injury.
RatSpinal cord injuryContusionSprague-Dawley and Wistar (MeSH indexed)Male and female (MeSH indexed)Intravenous5 kU of SOD1 per kg
Model: Moderate contusion spinal cord injury in rats; model details not stated in abstract
A single intravenous dose of double-coat SOD1 nanozyme prolonged circulation of active SOD1 (half-life 60 versus 6 min) and improved locomotor recovery while reducing swelling, cord compression and post-traumatic cyst formation after moderate spinal cord injury
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.