Characterization and in vivo efficacy of a heptapeptide ODT formulation for the treatment of neurogenic bladder dysfunction.
RatSpinal cord injuryComplete transectionSprague-DawleyFemalen = 17 rats total; per-group n not statedSublingual oral transmucosal; intravenous comparatorSublingual orally disintegrating tablets containing 0.1 to…Acute, in the same anaesthetised preparation after complete transection and det…
Model: Acute spinal cord injury with areflexic bladder: complete spinal cord transection at T9 to T10 after laminectomy under urethane anaesthesia, with isovolumetric bladder pressure recording at 70 per cent of functional bladder capacity
Sublingual peptide tablets produced a rapid dose-related neurokinin-2 mediated increase in bladder pressure in acutely spinalised rats that was reversed by the NK2 antagonist, although potency was much lower and onset slower than intravenous dosing
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