Zhenbao pill protects against acute spinal cord injury via regulating the expression of GPR17.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 49 rats total: first experiment n=21 in three groups of 7,…Intragastric oral gavage0.6 g/kg/day, selected from a dose range of 0.2, 0.4, 0.6 a…After induction of acute spinal cord injury; exact interval not stated
Model: Acute spinal cord injury by modified Allen weight-drop: laminectomy at T10, contusion with a 2.4 mm diameter impactor and 10 g weight dropped from 2.5 cm
Zhenbao pill improved hindlimb locomotor scores at all time points, reduced neuronal apoptosis and inflammatory mediators, raised the targeting microRNA and lowered GPR17, and these benefits were reversed by the microRNA inhibitor
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.