Trimethylene carbonate-caprolactone conduit with poly-p-dioxanone microfilaments to promote regeneration after spinal cord injury.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemale (MeSH indexed)Surgical implantation into the spinal cord cavityImplanted immediately after injury in the acute group, or 2 to 5 months after t…
Model: Cervical spinal cord injury with a small 2 to 3 mm cavity in the C3 to C4 segments, treated either acutely or 2 to 5 months after the initial surgery
The conduit supported regeneration of raphespinal and sensory axons after acute injury and mainly sensory axon regeneration after chronic injury, with reduced astrocyte activity and no change in microglial density, without added cells or neurotrophic factors
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