Protective effect of Malva sylvestris L. extract in ischemia-reperfusion induced acute kidney and remote liver injury.
RatIschaemia-reperfusionRenalWistarMalen = 35 rats total, 5 groups with n=7 per groupIntraperitoneal200, 400 or 600 mg/kg bodyweight30 min before induction of ischaemia
Model: 30 min of bilateral renal ischaemia followed by 24 h of reperfusion under pentobarbital anaesthesia with body temperature maintained at 37 plus or minus 1 degree Celsius
All three doses improved renal function, inflammation, oxidative stress and both renal and remote hepatic tissue damage after ischaemia-reperfusion, with 200 and 400 mg/kg outperforming 600 mg/kg
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.