Soluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury.
RatIschaemia-reperfusionOther / unspecifiedOutbred adult Wistarn = 61 rats total; per-group n not stated in the retrieved textIntravitreal injection2 ug or 4 ug per eye in a total volume of 4 uLDay 1 after the infarct
Model: Rat anterior ischaemic optic neuropathy induced by photodynamic therapy: rose bengal 2.5 mM in PBS at 1 mL/kg intravenously followed immediately by argon green laser to the optic disc at 532 nm, 500 micron spot, 80 mW, for 12 pulses of 1 s
A single intravitreal 4 ug dose given on day 1 preserved visual evoked potential amplitude and retinal nerve fibre layer thickness, increased retinal ganglion cell survival, reduced apoptosis, macrophage infiltration and optic nerve oedema, and up-regulated Nrf2, NQO1 and HO-1, with the 2 ug dose o…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.