Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.
MouseRadiationBALB/cFemaleIntravenous (tail vein)32 ug per mouse (1.6 mg/kg body weight) in vivo; 10 ug/ml i…First dose 24 h after irradiation
Model: Total body irradiation with 7.25 Gy from a caesium gamma irradiator at 4.18 Gy/min; in vitro work used lineage-negative bone marrow cells and primary fibroblasts irradiated at 3 to 5 Gy
Thioredoxin given 24 h after 7.25 Gy total body irradiation raised 30-day survival to 70% versus 25% in saline-treated mice (p = 0.0273). Treated mice showed higher white blood cell and platelet counts, more KSL and SLAM+KSL cells, more CFU-GM and CFU-GEMM colonies and greater bone marrow cellulari…
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