Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-kappaB and activation of nuclear factor erythroid 2-related factor 2.

Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-kappaB and activation of nuclear factor erythroid 2-related factor 2.

Model: D-galactosamine plus lipopolysaccharide induced acute liver injury in mice, with supporting in vitro work in RAW 264.7 macrophages and primary Kupffer cells

Hemistepsin A reduced nitric oxide, iNOS and COX-2 expression and proinflammatory cytokine secretion in Toll-like receptor ligand stimulated macrophages and Kupffer cells. In the D-galactosamine/LPS liver injury model it lessened hepatocyte degeneration and inflammatory cell infiltration and reduce…

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