Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages.
MouseWoundC57BL/6JMaleIntraperitoneal (colchicine); intravenous (clodronate liposomes)0.75 mg/kg in sterile saline; comparator clodronate liposom…Colchicine started 2 days before the incision; clodronate liposomes given 1 h b…
Model: Plantar incision model of postoperative pain: 5 mm longitudinal incision through skin and fascia of the right hind paw starting 2 mm from the heel, with elevation of the plantaris muscle and no suturing so wound repair could be assessed
Colchicine 0.75 mg/kg attenuated incision-induced mechanical hypersensitivity on day 1 and reduced Gr1-positive neutrophil infiltration at days 1 and 3 and Iba1 macrophage immunoreactivity at day 3, with lower IL1beta and CD86 mRNA. However it significantly delayed wound closure at day 3 and attenu…
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