Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury.
MouseOtherMaleInjection; specific route not stated in the retrieved text
Model: Acute retinal ganglion cell injury in the eye plus a chronic model of glaucoma; severity parameters not stated in the retrieved text
Retinal astrocyte conditioned medium contained a secreted neuroprotective signal identified by metabolomics as a lipid rather than a peptide neurotrophic factor, specifically lipoxins A4 and B4, which are synthesised in the inner retina and fall after injury. Injection of either lipoxin was suffici…
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.