Low intensity pulsed ultrasound (LIPUS) for the treatment of intervertebral disc degeneration.
RatOtherSprague-DawleyFemalen = Five rats in total; subset of two animals with successful s…Non-invasive transcutaneous ultrasound applied to the tail through coupling gel60 mW/cm2 spatial average intensity, 200 microsecond burst,…First exposure 30 min after the stab injury
Model: Rat tail intervertebral disc stab model of acute disc degeneration using a 20-gauge short-bevel needle inserted laterally under fluoroscopic guidance, with two of the three most proximal discs stabbed and the remaining disc used as control
Across all five animals gene expression trends favoured LIPUS but variation was large and no comparison reached significance. In the two animals judged to have a successful stab and a significant injury response, LIPUS significantly upregulated Col2a1 (p = 0.03) and downregulated TNF-alpha (p = 0.0…
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