Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
MixedChemical/toxinSprague-Dawley rats and C57BL/6 miceMale
Model: Thioacetamide-induced acute liver injury in rats and mice
Dioscin lowered serum ALT and AST and improved histopathological changes relative to the thioacetamide model groups in both rats and mice. It raised GSH, GSH-Px and SOD and reduced malondialdehyde, indicating reduced oxidative stress. Mechanistically it upregulated FXR and phospho-AMPKalpha with do…
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