4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes.
MouseWoundC57BL/6Topical100 microlitres of 5% carboxymethylcellulose gel containing…Immediately after wounding on day 0
Model: Full-thickness excisional dorsal skin wound, 10 mm circular punch
Topical 4-HBA accelerated wound closure more than PDGF-BB at day 3 (34% versus 29.4%) and combination treatment closed wounds about 10% faster than 4-HBA alone by day 6, with enhanced re-epithelialisation and angiogenesis
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