Enhancing the efficacy of AREDS antioxidants in light-induced retinal degeneration.
RatRadiationSprague-DawleyMaleOral (dietary supplement)Daily dietary supplement on a small cracker at daily recomm…Daily supplementation before acute intense light exposure (one week of AREDS pl…
Model: Photo-oxidative retinal damage: 6 hours of intense white light (9,000 lux) after 6 weeks rearing in low (20 lux) or high (200 lux) cyclic light
AREDS alone and zinc oxide alone at daily recommended levels were ineffective, whereas AREDS plus rosemary and zinc oxide plus rosemary reduced retinal damage and AREDS plus carnosic acid preserved visual cell proteins and retinal DNA
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