Evaluation of the systemic antiinflammatory effects of levosimendan in an experimental blunt thoracic trauma model.
RatOtherWistar albinon = 32 rats (four groups)IntravenousLow dose: 5 microgram/kg loading over 10 minutes then 0.05…
Model: Blunt thoracic trauma with pulmonary contusion
Levosimendan reduced alveolar congestion, haemorrhage and neutrophil infiltration and lowered serum IL-1beta (both doses) and IL-6 and NO (high dose), partially correcting pulmonary damage, although TNF-alpha and pulmonary NF-kappaB activation were not reduced
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.