Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition.
MouseEndotoxin/LPSC57BL/6malen = Group sizes not stated for the in vivo experiments; n=5 rep…Intraperitoneal in vivo10 mg/kg in vivo; in vitro vildagliptin 10 nM and linaglipt…Preventive protocol starting 1 day before the first lipopolysaccharide dose
Model: Systemic endotoxaemic lung injury and subsequent post-acute lung injury pulmonary fibrosis induced by intraperitoneal lipopolysaccharide from Escherichia coli O55:B5, 5 mg/kg for five consecutive days
Repeated lipopolysaccharide exposure increased CD26 expression in pulmonary vascular endothelial cells and produced prominent interstitial pulmonary fibrosis with increased endothelial-to-mesenchymal transition. Vildagliptin attenuated the fibrosis, reduced mesenchymal marker gene expression, resto…
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