The effect of adipose derived stromal vascular fraction on stasis zone in an experimental burn model.
RatBurnContact / flameSprague-Dawleyn = 20 burned rats (paired design) plus 5 donor rats for ADSVF…Local injection into the burn stasis zoneADSVF cells harvested from inguinal fat pads of donor rats;…30 minutes after burn induction
Model: Comb burn model creating dorsal thermal burn with interspersed stasis zones
ADSVF injection roughly doubled macroscopic stasis zone viability (57% versus 32%, P<0.01) and increased vessel counts, vascular density and epithelial thickness while reducing fibrosis and inflammatory cell density
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