Pretreatment of a matrix metalloproteases inhibitor and aprotinin attenuated the development of acute pancreatitis-induced lung injury in rat model.
RatChemical/toxinSprague-DawleymaleAprotinin 10 mg/kg; matrix metalloproteinase inhibitor 100…Pretreatment, given before induction of acute pancreatitis
Model: Acute pancreatitis induced by injection of sodium glycodeoxycholate into the pancreatic duct, with secondary acute lung injury
Pretreatment with either aprotinin or the matrix metalloproteinase inhibitor significantly reduced amylase, lactate dehydrogenase and the wet to dry weight ratio of lung and pancreas, prevented the pancreatitis-induced rise in lung interleukin-6, decreased accumulation of white blood cells, oxygen…
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