Diverging effects of enalapril or eplerenone in primary prevention against doxorubicin-induced cardiotoxicity.
MouseChemical/toxinC57BL/6 (MeSH indexed), including cardiomyocyte-specific mineralocorticoid receptor knockout transgenic miceMaleDoxorubicin 15 mg/kg single injection (acute) or 4 mg/kg pe…Drugs provided with the first dose of doxorubicin (primary prevention)
Model: Doxorubicin-induced cardiotoxicity: acute model with a single injection of doxorubicin 15 mg/kg; chronic model with five injections of doxorubicin 4 mg/kg per week
Neither mineralocorticoid receptor antagonism nor angiotensin converting enzyme inhibition protected against acute doxorubicin cardiotoxicity. In the chronic model eplerenone was not protective and raised plasma aldosterone and cardiac connective tissue growth factor, whereas enalapril preserved le…
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