Hydrogen Sulfide Protects Retinal Ganglion Cells Against Glaucomatous Injury In Vitro and In Vivo.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyFemaleIntravitreal injection
Model: Ocular hypertension induced by episcleral vein cauterisation for 7 weeks; acute retinal ischaemic injury and optic nerve crush in vivo; retinal explants exposed to elevated hydrostatic pressure or hydrogen peroxide in vitro
Intraocular pressure elevation caused significant retinal ganglion cell loss and a threefold upregulation of the hydrogen sulfide producing enzyme 3-mercaptosulfurtransferase. GYY4137 protected retinal ganglion cells in a concentration-dependent manner in vitro and preserved cells after acute ischa…
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