Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury.
MouseCrushOther / unspecifiedC57BL/6Intraocular injection2 microlitres of 7.2 mM edaravone3 minutes after optic nerve injury
Model: Optic nerve injury (crush) in adult mice
A single intraocular injection of edaravone given 3 minutes after optic nerve injury reduced reactive oxygen species production, retinal ganglion cell death and inner retinal degeneration, and suppressed activation of the ASK1-p38 MAPK pathway.
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